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1

Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial IntegrityNovelty and Significance

Nakao, Kazuhiro, Kuwahara, Koichiro, Nishikimi, Toshio, Nakagawa, Yasuaki, Kinoshita, Hideyuki, Minami, Takeya, Kuwabara, Yoshihiro, Yamada, Chinatsu, Yamada, Yuko, Tokudome, Takeshi, Nagai-Okatani, C

Journal:

Year:

2017

Language:

english

File:

PDF, 910 KB

english, 2017

2

Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition

Kato, Yukiko, Mori, Kiyoshi, Kasahara, Masato, Osaki, Keisuke, Ishii, Akira, Mori, Keita P., Toda, Naohiro, Ohno, Shoko, Kuwabara, Takashige, Tokudome, Takeshi, Kishimoto, Ichiro, Saleem, Moin A., Mat

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.47 MB

english, 2017

3

Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet

Bae, Cho-Rong, Hino, Jun, Hosoda, Hiroshi, Son, Cheol, Makino, Hisashi, Tokudome, Takeshi, Tomita, Tsutomu, Hosoda, Kiminori, Miyazato, Mikiya, Kangawa, Kenji

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 3.94 MB

english, 2018

4

Physiological significance of ghrelin in the cardiovascular system

TOKUDOME, Takeshi, KANGAWA, Kenji

Journal:

Proceedings of the Japan Academy Series B Physical and Biological Sciences

Year:

2019

File:

PDF, 2.87 MB

2019

5

Depression, inflammation, and pain in patients with rheumatoid arthritis

Masayo Kojima, Toshihisa Kojima, Sadao Suzuki, Takeshi Oguchi, Michinari Oba, Hiroki Tsuchiya, Fumiaki Sugiura, Yasuhide Kanayama, Toshiaki A. Furukawa, Shinkan Tokudome, Naoki Ishiguro

Journal:

Arthritis Care & Research

Year:

2009

Language:

english

File:

PDF, 99 KB

english, 2009

6

Re: Helicobacter pylori infection and gastric cancer: Facing the enigmas

Shinkan Tokudome, Kiyonori Kuriki, Sadao Suzuki, Susumu Akasaka, Hiroshi Kosaka, Hideki Ishikawa, Takesumi Yoshimura, Takeshi Azuma, Do Duc Van, Nguyen Cong Khan, Supannee Sriamporn, Surapon Wiangnon,

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 46 KB

english, 2004

7

Concomitant carriage of hepatitis B virus and human T-lymphotropic virus type I among blood donors in Kitakyushu, Japan

Takeshi Asakura, Kazuhiko Tachibana, Shuji Watanabe, Daiichiro Teshima, Masato Ikeda, Shinkan Tokudome

Journal:

Journal of Infection

Year:

1991

Language:

english

File:

PDF, 271 KB

english, 1991

8

Detection of autoantibody to aldolase B in sera from patients with troglitazone-induced liver dysfunction

Rawiwan Maniratanachote, Ayaka Shibata, Shuichi Kaneko, Ikuo Yamamori, Takanobu Wakasugi, Takeshi Sawazaki, Kanefusa Katoh, Shogo Tokudome, Miki Nakajima, Tsuyoshi Yokoi

Journal:

Year:

2005

Language:

english

File:

PDF, 330 KB

english, 2005

9

C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons

Ichiro Kishimoto, Takeshi Tokudome, Hideki Chusho, Kazuwa Nakao, Kenji Kangawa

Journal:

BMC Pharmacology

Year:

2009

Language:

english

File:

PDF, 63 KB

english, 2009

10

Follow-up of asymptomatic HTLV-I carriers among blood donors in Kyushu, Japan

Shinkan Tokudome, Yoshiaki Maeda, Kenji Fukada, Daiichiro Teshima, Takeshi Asakura, Eizaburo Sueoka, Yasuo Motomura, Yukihiko Kusumoto, Yumiko Imamura, Tetsuyuki Kiyokawa, Masato Ikeda, Osamu Tokunaga

Journal:

Cancer Causes & Control

Year:

1991

Language:

english

File:

PDF, 297 KB

english, 1991

11

Identification of Helicobacter pylori and the cagA genotype in gastric biopsies using highly sensitive real-time PCR as a new diagnostic tool

Shiho Yamazaki, Shunji Kato, Norio Matsukura, Masahiro Ohtani, Yoshiyuki Ito, Hiroyuki Suto, Yukinao Yamazaki, Akiyo Yamakawa, Shinkan Tokudome, Hideaki Higashi, Masanori Hatakeyama, Takeshi Azuma

Journal:

FEMS Immunology & Medical Microbiology

Year:

2005

Language:

english

File:

PDF, 363 KB

english, 2005

12

Natriuretic peptide system: an overview of studies using genetically engineered animal models

Ichiro Kishimoto, Takeshi Tokudome, Kazuwa Nakao, Kenji Kangawa

Journal:

Year:

2011

Language:

english

File:

PDF, 262 KB

english, 2011

13

Effects of seat belts worn by pregnant drivers during low-impact collisions

Yasuki Motozawa, Masahito Hitosugi, Takeshi Abe, Shogo Tokudome

Journal:

American Journal of Obstetrics and Gynecology

Year:

2010

Language:

english

File:

PDF, 677 KB

english, 2010

14

Ghrelin and cardiovascular diseases

Ichiro Kishimoto, Takeshi Tokudome, Hiroshi Hosoda, Mikiya Miyazato, Kenji Kangawa

Journal:

Journal of Cardiology

Year:

2012

Language:

english

File:

PDF, 393 KB

english, 2012

15

Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits

Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Takashi Sonobe, Atsunori Kamiya, Toshiaki Shishido, Takeshi Tokudome, Hiroshi Hosoda, Mikiyasu Shirai, Kenji Kangawa, Masaru Sugimachi

Journal:

Autonomic Neuroscience

Year:

2011

Language:

english

File:

PDF, 503 KB

english, 2011

16

Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia

Shinkan Tokudome, Soeripto, F.X. Ediati Triningsih, Indrawati Ananta, Sadao Suzuki, Kiyonori Kuriki, Susumu Akasaka, Hiroshi Kosaka, Hideki Ishikawa, Takeshi Azuma, Malcolm A. Moore

Journal:

Year:

2005

Language:

english

File:

PDF, 84 KB

english, 2005

17

Regulator of G-protein Signaling 4 Mediates Antihypertrophic Effect of Endogenous Natriuretic Peptides in the Heart

Takeshi Tokudome, Ichiro Kishimoto, Takeshi Horio, Masakazu Kohno, Kazuwa Nakao, Kenji Kangawa

Journal:

Journal of Cardiac Failure

Year:

2007

Language:

english

File:

PDF, 29 KB

english, 2007

18

Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: Comparison with C-reactive protein

Hidenori Nishida, Takeshi Horio, Yoshihiko Suzuki, Yoshio Iwashima, Takeshi Tokudome, Fumiki Yoshihara, Satoko Nakamura, Yuhei Kawano

Journal:

Year:

2011

Language:

english

File:

PDF, 207 KB

english, 2011

19

Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis

Masayo Kojima, Toshihisa Kojima, Naoki Ishiguro, Takeshi Oguchi, Michinari Oba, Hiroki Tsuchiya, Fumiaki Sugiura, Toshiaki A. Furukawa, Sadao Suzuki, Shinkan Tokudome

Journal:

Journal of Psychosomatic Research

Year:

2009

Language:

english

File:

PDF, 211 KB

english, 2009

20

Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts

Takeshi Tokudome, Takeshi Horio, Fumiki Yoshihara, Shin-ichi Suga, Yuhei Kawano, Masakazu Kohno, Kenji Kangawa

Journal:

Year:

2004

Language:

english

File:

PDF, 216 KB

english, 2004

21

Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts

Takeshi Horio, Toshiyuki Maki, Ichiro Kishimoto, Takeshi Tokudome, Hiroyuki Okumura, Fumiki Yoshihara, Shin-ichi Suga, Satoshi Takeo, Yuhei Kawano, Kenji Kangawa

Journal:

Regulatory Peptides

Year:

2005

Language:

english

File:

PDF, 445 KB

english, 2005

22

Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy

Fumiki Yoshihara, Toshio Nishikimi, Ichiro Okano, Jun Hino, Takeshi Horio, Takeshi Tokudome, Shin-ichi Suga, Hiroaki Matsuoka, Kenji Kangawa, Yuhei Kawano

Journal:

Regulatory Peptides

Year:

2005

Language:

english

File:

PDF, 281 KB

english, 2005

23

Chronic administration of adrenomedullin attenuates the hypertension and increases renal nitric oxide synthase in Dahl salt-sensitive rats

Fumiki Yoshihara, Shin-ichi Suga, Naomi Yasui, Takeshi Horio, Takeshi Tokudome, Toshio Nishikimi, Yuhei Kawano, Kenji Kangawa

Journal:

Regulatory Peptides

Year:

2005

Language:

english

File:

PDF, 371 KB

english, 2005

24

Glucocorticoid protects the heart from ischemia-reperfusion injury via activation of PGD2 biosynthesis

Shintaro Morizane, Motoaki Sano, Hidenori Moriyama, Tomohiro Matsuhashi, Satori Tokudome, Ken Shinmura, Takaharu Katayama, Takeshi Suzuki, Keiichi Fukuda

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2008

Language:

english

File:

PDF, 48 KB

english, 2008

25

Heterogeneity of liver disorder in type B niemann-pick disease

Tsutomu Takahashi, Kenji Akiyama, Masako Tomihara, Takahiro Tokudome, Fujihiko Nishinomiya, Yusaku Tazawa, Kenichi Horinouchi, Takeshi Sakiyama, Goro Takada

Journal:

Human Pathology

Year:

1997

Language:

english

File:

PDF, 3.94 MB

english, 1997

26

Green Tea Consumption and Serum Lipids and Lipoproteins in a Population of Healthy Workers in Japan

Shoji Tokunaga, Ian R White, Chris Frost, Keitaro Tanaka, Suminori Kono, Shinkan Tokudome, Takashi Akamatsu, Takeshi Moriyama, Hidemoto Zakouji

Journal:

Annals of Epidemiology

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

27

C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction

Takeshi Soeki, Ichiro Kishimoto, Hiroyuki Okumura, Takeshi Tokudome, Takeshi Horio, Kenji Mori, Kenji Kangawa

Journal:

Journal of the American College of Cardiology

Year:

2005

Language:

english

File:

PDF, 531 KB

english, 2005

28

Inhibition of left ventricular remodeling in volume overload by angiotensin-converting enzyme inhibitor in rats with aortic regurgitation

Kazushi Murakami, Katsufumi Mizushige, Takahisa Noma, Atsufumi Tomohiro, Takeshi Tokudome, Hirohide Matsuo

Journal:

Journal of Cardiac Failure

Year:

1999

Language:

english

File:

PDF, 120 KB

english, 1999

29

[American Institute of Aeronautics and Astronautics 44th AIAA Aerospace Sciences Meeting and Exhibit - Reno, Nevada (09 January 2006 - 12 January 2006)] 44th AIAA Aerospace Sciences Meeting and Exhibit - Aerodynamic Characteristics of the Modified Combined Cycle Engines in Ejector-Jet Mode

Tani, Kouichiro, Kanda, Takeshi, Tokudome, Shin-ichiro

Year:

2006

Language:

english

File:

PDF, 612 KB

english, 2006

30

Endothelial GC-A can be a therapeutic target for metabolic syndrome

Takeshi Tokudome,Kentaro Otani,Ichiro Kishimoto…

Journal:

BMC Pharmacology and Toxicology

Year:

2013

Language:

english

File:

PDF, 64 KB

english, 2013

31

Protective role of endogenous cardiac natriuretic peptide/GC-A system on the maternal heart during the postpartum period

Otani, Kentaro, Tokudome, Takeshi, Kishimoto, Ichiro, Mao, Yuanjie, Yamahara, Kenichi, Nakao, Kazuwa, Kangawa, Kenji

Journal:

BMC Pharmacology and Toxicology

Year:

2013

Language:

english

File:

PDF, 135 KB

english, 2013

32

One dose of oral hexarelin protects chronic cardiac function after myocardial infarction

Mao, Yuanjie, Tokudome, Takeshi, Kishimoto, Ichiro, Otani, Kentaro, Miyazato, Mikiya, Kangawa, Kenji

Journal:

Year:

2014

Language:

english

File:

PDF, 983 KB

english, 2014

33

PATIENT AND DOCTOR

Mao, Yuanjie, Tokudome, Takeshi, Kishimoto, Ichiro, Otani, Kentaro, Miyazato, Mikiya, Kangawa, Kenji

Journal:

Year:

1935

Language:

english

File:

PDF, 207 KB

english, 1935

34

Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury

Nojiri, Takashi, Hosoda, Hiroshi, Tokudome, Takeshi, Miura, Koichi, Ishikane, Shin, Kimura, Toru, Shintani, Yasushi, Inoue, Masayoshi, Sawabata, Noriyoshi, Miyazato, Mikiya, Okumura, Meinoshin, Kangaw

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.56 MB

english, 2014

35

T1038 Changes Over a 12 Year Period in First-Line Eradication Rates for H. pylori Infection Based on Triple Therapy With a PPI, AmpC and CAM

Sasaki, Makoto, Kamiya, Takeshi, Kataoka, Hiromi, Tanida, Satoshi, Mizoshita, Tsutomu, Ogasawara, Naotaka, Funaki, Yasushi, Iida, Akihito, Mizuno, Mari, Tokudome, Kentaro, Hijikata, Yasutaka, Masui, R

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 120 KB

english, 2010

36

Stereoselective Formation of Tetrahydrofuran Rings via [3 + 2] Annulation: Total Synthesis of Plakortone L

Sugimura, Hideyuki, Sato, Shougo, Tokudome, Kensei, Yamada, Takeshi

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 536 KB

english, 2014

37

Follow-up of Asymptomatic HTLV-I Carriers among Blood Donors in Kyushu, Japan

Shinkan Tokudome, Yoshiaki Maeda, Kenji Fukada, Daiichiro Teshima, Takeshi Asakura, Eizaburo Sueoka, Yasuo Motomura, Yukihiko Kusumoto, Yumiko Imamura, Tetsuyuki Kiyokawa, Masato Ikeda and Osamu Tokun

Journal:

Cancer Causes & Control

Year:

1991

Language:

english

File:

PDF, 593 KB

english, 1991

38

Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides

Yoshihara, Fumiki, Tokudome, Takeshi, Kishimoto, Ichiro, Otani, Kentaro, Kuwabara, Atsunori, Horio, Takeshi, Kawano, Yuhei, Kangawa, Kenji

Journal:

Clinical and Experimental Nephrology

Year:

2015

Language:

english

File:

PDF, 2.58 MB

english, 2015

39

Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury

Nojiri, Takashi, Hosoda, Hiroshi, Kimura, Toru, Miura, Koichi, Ishikane, Shin, Tokudome, Takeshi, Shintani, Yasushi, Inoue, Masayoshi, Miyazato, Mikiya, Okumura, Meinoshin, Kangawa, Kenji

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 477 KB

english, 2015

40

Dietary n-3/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: A randomized controlled trial in polypectomized participants

Tokudome, Shinkan, Kuriki, Kiyonori, Yokoyama, Yoshifumi, Sasaki, Makoto, Joh, Takashi, Kamiya, Takeshi, Cheng, Jinglei, Ogawa, Kumiko, Shirai, Tomoyuki, Imaeda, Nahomi, Goto, Chiho, Tokudome, Yuko, I

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2015

Language:

english

File:

PDF, 425 KB

english, 2015

41

Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells

Nojiri, Takashi, Hosoda, Hiroshi, Tokudome, Takeshi, Miura, Koichi, Ishikane, Shin, Otani, Kentaro, Kishimoto, Ichiro, Shintani, Yasushi, Inoue, Masayoshi, Kimura, Toru, Sawabata, Noriyoshi, Minami, M

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

42

Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model

Tokudome, Yoshihiro, Uchida, Raina, Yokote, Takeshi, Todo, Hiroaki, Hada, Nobuko, Kon, Tatsuhiko, Yasuda, Junko, Hayashi, Hidenori, Hashimoto, Fumie, Sugibayashi, Kenji

Journal:

Journal of Liposome Research

Year:

2010

Language:

english

File:

PDF, 748 KB

english, 2010

43

Excessive Sympathoactivation and Deteriorated Heart Function After Myocardial Infarction in Male Ghrelin Knockout Mice

Mao, Yuanjie, Tokudome, Takeshi, Otani, Kentaro, Kishimoto, Ichiro, Miyazato, Mikiya, Kangawa, Kenji

Journal:

Year:

2013

Language:

english

File:

PDF, 445 KB

english, 2013

44

Therapeutic potential of ghrelin in cardiac diseases

Kishimoto, Ichiro, Tokudome, Takeshi, Schwenke, Daryl O, Takeshi, Soeki, Hosoda, Hiroshi, Nagaya, Noritoshi, Kangawa, Kenji

Journal:

Expert Review of Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

45

Adrenomedullin Inhibits Doxorubicin-Induced Cultured Rat Cardiac Myocyte Apoptosis via a cAMP-Dependent Mechanism

Tokudome, Takeshi, Horio, Takeshi, Yoshihara, Fumiki, Suga, Shin-ichi, Kawano, Yuhei, Kohno, Masakazu, Kangawa, Kenji

Journal:

Year:

2002

Language:

english

File:

PDF, 303 KB

english, 2002

46

Hexarelin Treatment in Male Ghrelin Knockout Mice after Myocardial Infarction

Mao, Yuanjie, Tokudome, Takeshi, Kishimoto, Ichiro, Otani, Kentaro, Hosoda, Hiroshi, Nagai, Chiaki, Minamino, Naoto, Miyazato, Mikiya, Kangawa, Kenji

Journal:

Year:

2013

Language:

english

File:

PDF, 536 KB

english, 2013

47

Ghrelin Prevents Incidence of Malignant Arrhythmia after Acute Myocardial Infarction through Vagal Afferent Nerves

Mao, Yuanjie, Tokudome, Takeshi, Otani, Kentaro, Kishimoto, Ichiro, Nakanishi, Michio, Hosoda, Hiroshi, Miyazato, Mikiya, Kangawa, Kenji

Journal:

Year:

2012

Language:

english

File:

PDF, 1.56 MB

english, 2012

48

Early Ghrelin Treatment after Myocardial Infarction Prevents an Increase in Cardiac Sympathetic Tone and Reduces Mortality

Schwenke, Daryl O., Tokudome, Takeshi, Kishimoto, Ichiro, Horio, Takeshi, Shirai, Mikiyasu, Cragg, Patricia A., Kangawa, Kenji

Journal:

Year:

2008

Language:

english

File:

PDF, 299 KB

english, 2008

49

Exogenous Ghrelin Attenuates the Progression of Chronic Hypoxia-Induced Pulmonary Hypertension in Conscious Rats

Schwenke, Daryl O., Tokudome, Takeshi, Shirai, Mikiyasu, Hosoda, Hiroshi, Horio, Takeshi, Kishimoto, Ichiro, Kangawa, Kenji

Journal:

Year:

2008

Language:

english

File:

PDF, 414 KB

english, 2008

50

Ventricular Nonmyocytes Inhibit Doxorubicin-Induced Myocyte Apoptosis: Involvement of Endogenous Endothelin-1 as a Paracrine Factor

Tokudome, Takeshi, Horio, Takeshi, Fukunaga, Megumu, Okumura, Hiroyuki, Hino, Jun, Mori, Kenji, Yoshihara, Fumiki, Suga, Shin-Ichi, Kawano, Yuhei, Kohno, Masakazu, Kangawa, Kenji

Journal:

Year:

2004

Language:

english

File:

PDF, 588 KB

english, 2004

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